Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 12/20 | 0.42 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | FLT1 | P17948 | 3/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025431 | 0.82 | SCARB1 (0.46) | SCARB1HRH3 | |
| SCHEMBL4029927 | 0.82 | SCARB1 (0.43) | SCARB1SMN1; SMN2HRH3 | |
| SCHEMBL4204074 | 0.81 | ALDH1A1 (0.45) | SCARB1 | |
| SCHEMBL4030140 | 0.80 | SCARB1 (0.59) | SCARB1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL4033009 | 0.79 | SCARB1 (0.41) | SCARB1HRH3 | |
| SCHEMBL4023327 | 0.78 | HSD17B10 (0.41) | SCARB1 | |
| SCHEMBL13746785 | 0.73 | SCARB1 (0.38) | SCARB1 | |
| SCHEMBL13747863 | 0.71 | SCARB1 (0.46) | SCARB1SMN1; SMN2HRH3 | |
| SCHEMBL13747173 | 0.69 | SCARB1 (0.58) | SCARB1HRH3 | |
| SCHEMBL29746275 | 0.64 | PARP1 (0.41) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |