Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025431 | 0.86 | SCARB1 (0.46) | HSD17B10KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL4029927 | 0.86 | SCARB1 (0.43) | HSD17B10KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL4033009 | 0.83 | SCARB1 (0.41) | HSD17B10RORCKDM4ERAB9AALDH1A1 | |
| SCHEMBL4204074 | 0.80 | ALDH1A1 (0.45) | KDM4EALDH1A1KMT2ASCARB1POLB | |
| SCHEMBL4031956 | 0.78 | THRB (0.42) | SCARB1 | |
| SCHEMBL4024437 | 0.76 | HSD17B10 (0.46) | HSD17B10RORCKDM4ERAB9AALDH1A1 | |
| SCHEMBL13746785 | 0.76 | SCARB1 (0.38) | HSD17B10KDM4EALDH1A1KMT2ASCARB1 | |
| SCHEMBL13747863 | 0.74 | SCARB1 (0.46) | HSD17B10KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL5794717 | 0.74 | GALK1 (0.39) | HSD17B10KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL6756508 | 0.73 | SCARB1 (0.63) | HSD17B10RORCKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |