Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 8/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.43 |
| ▸ | GSK3A | P49840 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.41 |
| ▸ | CDK1 | P06493 | 5/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9148539 | 0.89 | AR (0.43) | ARMAPK10RIPK1MAPT | |
| SCHEMBL20602364 | 0.79 | MAPT (0.59) | GSK3BCDK5CDK5R1GSK3AMAPT | |
| SCHEMBL4026285 | 0.79 | BAZ2B (0.49) | MAPK10MAPTMEN1KMT2A | |
| SCHEMBL17026942 | 0.78 | KDM4E (0.49) | MAPTL3MBTL1MEN1KMT2ACFTR | |
| SCHEMBL4032070 | 0.77 | RORC (0.57) | ARMAPK10RIPK1GSK3BCDK5 | |
| SCHEMBL541264 | 0.77 | MAPT (0.59) | ARMAPK10RIPK1GSK3BCDK5 | |
| SCHEMBL4024352 | 0.77 | HSD17B10 (0.56) | MAPTMEN1KMT2A | |
| SCHEMBL17026844 | 0.76 | KIF11 (0.46) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL31510880 | 0.75 | HTR2A (0.51) | MAPTMEN1KMT2A | |
| SCHEMBL31510878 | 0.75 | HTR2A (0.51) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |