Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030768 | 0.81 | ERCC1 (0.57) | COMTCASRMEN1GAAKMT2A | |
| SCHEMBL4026584 | 0.80 | COMT (0.48) | COMTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL4027881 | 0.78 | ERCC1 (0.40) | ERCC1FEN1ERCC4HSD17B10ALDH1A1 | |
| SCHEMBL4026648 | 0.78 | NTRK1 (0.44) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4032043 | 0.75 | ERCC1 (0.67) | MEN1KMT2AERCC1FEN1ERCC4 | |
| SCHEMBL4032912 | 0.75 | LMNA (0.44) | MEN1GAAKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL6690246 | 0.71 | ERCC1 (0.42) | COMTCASRMEN1GAAKMT2A | |
| SCHEMBL4027681 | 0.71 | ERCC1 (0.41) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL4029257 | 0.71 | FEN1 (0.44) | MEN1GAAKMT2AERCC1FEN1 | |
| SCHEMBL6690248 | 0.70 | ADORA2A (0.40) | COMTCASRMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | claimed |