Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030138 | 0.81 | ERCC1 (0.57) | LMNAHIF1AALDH1A1TSHRMEN1 | |
| SCHEMBL4032043 | 0.75 | ERCC1 (0.67) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4032344 | 0.75 | COMT (0.42) | LMNAALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL4027881 | 0.72 | ERCC1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10ADORA3 | |
| SCHEMBL4029257 | 0.71 | FEN1 (0.44) | ALDH1A1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL4027681 | 0.71 | ERCC1 (0.41) | ALDH1A1KMT2ATDP1RAB9ANPC1 | |
| SCHEMBL4028118 | 0.70 | ERCC1 (0.40) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL4031571 | 0.69 | ERCC1 (0.40) | ALDH1A1MAPTHPGD | |
| SCHEMBL4028019 | 0.68 | FEN1 (0.39) | ALOX15HSD17B10MAPK1 | |
| SCHEMBL4026147 | 0.68 | FEN1 (0.39) | LMNAALDH1A1TSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | claimed |