Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.62 |
| ▸ | MMP3 | P08254 | 5/20 | 0.62 |
| ▸ | MMP7 | P09237 | 5/20 | 0.62 |
| ▸ | MMP9 | P14780 | 5/20 | 0.62 |
| ▸ | MMP13 | P45452 | 3/20 | 0.62 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437981 | 0.91 | MMP1 (0.58) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL2440987 | 0.90 | FKBP1A (0.53) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL4035295 | 0.88 | MMP1 (0.60) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL4033190 | 0.85 | MAPT (0.65) | ALDH1A1USP2 | |
| SCHEMBL2439810 | 0.85 | FKBP1A (0.53) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL2442409 | 0.85 | FKBP1A (0.53) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL4032527 | 0.85 | USP2 (0.60) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL2440508 | 0.85 | MMP1 (0.54) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL2437656 | 0.85 | MMP1 (0.54) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL4032579 | 0.85 | ALDH1A1 (0.56) | MMP1MMP3MMP7MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2007-06-21 | — | — | US | claimed |
| US-8404690-B2 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2013-03-26 | — | — | US | disclosed |
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | disclosed |
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2007-06-21 | — | — | US | disclosed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | P2RX5, P2RX2, NPY5R | MMP1 3474/4885MMP3 2393/4885MMP7 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.