Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188561 | 0.78 | SCARB1 (0.67) | SCARB1HSD17B10NPC1DRD3 | |
| SCHEMBL4031809 | 0.78 | SCARB1 (0.62) | SCARB1POLBHSD17B10NPC1RAD52 | |
| SCHEMBL4203284 | 0.70 | SCARB1 (0.67) | SCARB1HSD17B10NPC1DRD3 | |
| SCHEMBL4780961 | 0.70 | SCARB1 (0.61) | SCARB1POLBKDM4EALDH1A1ALOX15 | |
| SCHEMBL22511693 | 0.67 | RORC (0.56) | SCARB1POLBKDM4EALDH1A1ALOX15 | |
| SCHEMBL4726921 | 0.66 | SCARB1 (0.46) | SCARB1ALDH1A1RAB9ANPC1PTGER4 | |
| SCHEMBL2020046 | 0.65 | CNR1 (0.55) | CNR1CNR2 | |
| SCHEMBL4025480 | 0.65 | SCARB1 (0.61) | SCARB1HSD17B10NPC1 | |
| SCHEMBL4032588 | 0.64 | SCARB1 (0.61) | SCARB1KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL4728860 | 0.64 | SCARB1 (0.61) | SCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |