Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036870 | 0.89 | MAPK1 (0.42) | RAB9AALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL4033684 | 0.88 | NPC1 (0.39) | AKR1C3AKR1C2NPC1RAB9AALDH1A1 | |
| SCHEMBL4027903 | 0.85 | HTT (0.45) | RAB9AALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL4028121 | 0.80 | LPAR1 (0.44) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4033561 | 0.78 | LPAR1 (0.42) | NPC1ALDH1A1SMN1; SMN2MEN1HTT | |
| SCHEMBL15437794 | 0.77 | LPAR1 (0.41) | NPC1RAB9AMAPTPKMKMT2A | |
| SCHEMBL4031919 | 0.75 | TRPA1 (0.50) | ALDH1A1MAPTPKMLMNALPAR1 | |
| SCHEMBL4033303 | 0.74 | LPAR1 (0.74) | AKR1C3AKR1C2NPC1RAB9AALDH1A1 | |
| SCHEMBL4030969 | 0.73 | LPAR1 (0.38) | NPC1RAB9AALDH1A1PKMMEN1 | |
| SCHEMBL4030555 | 0.73 | MAPT (0.47) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |