Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386216 | 0.84 | MAPT (0.46) | MAPTMMP8POLBPIN1PPARG | |
| SCHEMBL14147393 | 0.82 | MMP8 (0.50) | MMP8L3MBTL1PIN1MEN1KMT2A | |
| SCHEMBL2672684 | 0.80 | HCAR2 (0.42) | MAPTMMP8POLBKDM4EPPARG | |
| SCHEMBL335398 | 0.79 | MAPT (0.51) | MAPTMMP8PPARGPPARANPC1 | |
| SCHEMBL1294074 | 0.79 | MAPT (0.43) | MAPTMMP8L3MBTL1PPARA | |
| SCHEMBL2828887 | 0.78 | LDHA (0.44) | MAPTMMP8PPARGPPARAMEN1 | |
| SCHEMBL3714556 | 0.78 | MAPT (0.40) | MAPTPOLBKDM4EPPARGPPARA | |
| SCHEMBL4035939 | 0.75 | MMP8 (0.49) | MMP8L3MBTL1PIN1MEN1KMT2A | |
| SCHEMBL16569848 | 0.75 | PKM (0.38) | MAPTL3MBTL1PPARGPPARAEPHX2 | |
| SCHEMBL7387704 | 0.74 | CTNNB1 (0.55) | MAPTMMP8L3MBTL1KDM4EPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034998-A1 | 1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008079427-A1 | 1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-03 | — | — | WO | disclosed |