Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451473 | 0.86 | POLB (0.54) | SIGMAR1POLBGAAKMT2ALMNA | |
| SCHEMBL5874855 | 0.86 | RXFP1 (0.47) | HTR6HTR3EHTR3BTSHRHTR3A | |
| SCHEMBL10714629 | 0.85 | POLB (0.56) | SIGMAR1POLBGAAKMT2ALMNA | |
| SCHEMBL5875374 | 0.80 | TSHR (0.47) | TSHRHSD17B10SIGMAR1GAAKMT2A | |
| SCHEMBL27892691 | 0.79 | HTT (0.44) | HTR7SIGMAR1KMT2ALMNAALDH1A1 | |
| SCHEMBL3576603 | 0.77 | ALDH1A1 (0.62) | SIGMAR1POLBKMT2ALMNAALDH1A1 | |
| SCHEMBL29004525 | 0.77 | ADRB1 (0.46) | CYP1A2HTR1ACYP2D6HTR3AKMT2A | |
| Hydrochloric Acid SCHEMBL9035292 | 0.76 | ALDH1A1 (0.61) | SIGMAR1POLBKMT2ALMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL1193388 | 0.76 | ALDH1A1 (0.61) | SIGMAR1POLBKMT2ALMNAALDH1A1 | |
| SCHEMBL24120719 | 0.74 | SIGMAR1 (0.56) | HTR6HTR3EHTR3BTSHRHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010519-A2 | SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120655-A2 | SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-10-25 | — | — | WO | disclosed |