Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | GCGR | P47871 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10714629 | 0.98 | POLB (0.56) | POLBLMNAGAAKMT2ANR4A1 | |
| SCHEMBL4035954 | 0.86 | HTR6 (0.46) | POLBLMNAGAAKMT2ANR4A1 | |
| SCHEMBL5875070 | 0.83 | NPC1 (0.44) | POLBLMNAKMT2AALDH1A1HTT | |
| SCHEMBL27604472 | 0.78 | POLB (0.45) | POLBLMNAGAAKMT2ANR4A1 | |
| SCHEMBL5874810 | 0.77 | NPC1 (0.55) | POLBLMNAGAAKMT2AALDH1A1 | |
| SCHEMBL1665838 | 0.77 | TSHR (0.43) | LMNAKMT2AALDH1A1HTTHPGD | |
| SCHEMBL9391593 | 0.76 | KMT2A (0.48) | POLBLMNAGAAKMT2ANR4A1 | |
| SCHEMBL27981018 | 0.75 | HTT (0.50) | LMNAGAAALDH1A1HTT | |
| SCHEMBL137605 | 0.75 | NR4A1 (0.63) | POLBLMNAGAAKMT2ANR4A1 | |
| SCHEMBL5987790 | 0.75 | NR4A1 (0.63) | POLBGAAKMT2ANR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | claimed |