Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.32 |
| ▸ | ALAD | P13716 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623033 | 0.79 | TSHR (0.52) | TSHRGPR35ALADCES2CES1 | |
| SCHEMBL18701591 | 0.77 | MEN1 (0.34) | TSHRANO1MEN1KMT2ACES2 | |
| SCHEMBL28196417 | 0.76 | TSHR (0.65) | TSHRKMT2AGPR35ALADCES2 | |
| SCHEMBL17398273 | 0.74 | TSHR (0.47) | TSHRMEN1KMT2AGPR35DAO | |
| SCHEMBL18701622 | 0.74 | KEAP1 (0.38) | ANO1MEN1KMT2AGPR35ALAD | |
| SCHEMBL2001851 | 0.71 | TSHR (0.44) | TSHRMEN1KMT2AGPR35CES2 | |
| SCHEMBL6861221 | 0.66 | — | — | |
| SCHEMBL19085034 | 0.65 | TSHR (0.42) | TSHRGPR35DAO | |
| SCHEMBL516974 | 0.65 | DGAT1 (0.42) | GPR35 | |
| SCHEMBL16414224 | 0.64 | TSHR (0.40) | TSHRMEN1KMT2AGPR35CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029572-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007143597-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |