Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033217 | 0.88 | DAO (0.50) | DAOHRH4DYRK1AMAP2K1CDK5 | |
| SCHEMBL4038601 | 0.86 | DAO (0.51) | DAOHRH4MAP2K1KDM4EMAP2 | |
| SCHEMBL3836490 | 0.77 | FLT3 (0.50) | DAOFGFR1KDM4EMAPT | |
| SCHEMBL1884988 | 0.76 | HRH4 (0.56) | DAOHRH4DYRK1AMAP2K1CDK5 | |
| SCHEMBL23212302 | 0.74 | HRH4 (0.55) | DAOHRH4DYRK1AMAP2K1CDK5 | |
| SCHEMBL29079881 | 0.74 | DAO (0.49) | DAOHRH4DYRK1AAURKAPIM1 | |
| SCHEMBL7020841 | 0.74 | DAO (0.45) | DAOHRH4DYRK1ACLK2KDM5A | |
| SCHEMBL3141113 | 0.73 | DAO (0.51) | DAOHRH4MAP2K1DRD2DRD3 | |
| SCHEMBL28690110 | 0.73 | HRH4 (0.42) | HRH4DYRK1A | |
| SCHEMBL35211818 | 0.72 | DAO (0.62) | DAOHRH4DYRK1AMAP2K1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |