SCHEMBL4038601

SCHEMBL4038601

O=C(O)Oc1cc2ccncc2[nH]1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.51
HRH4 Q9H3N8 1/20 0.44
NR3C1 P04150 2/20 0.38
PGR P06401 1/20 0.38
NR3C2 P08235 1/20 0.38
KDM5A P29375 2/20 0.37
DRD2 P14416 2/20 0.37
DRD3 P35462 2/20 0.37
MAPT P10636 1/20 0.37
SNCA P37840 1/20 0.37
MAP2K1 Q02750 1/20 0.35
KDM4E B2RXH2 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
NCOR2 Q9Y618 1/20 0.35
PARP1 P09874 1/20 0.35
CSNK2A1 P68400 1/20 0.35
HASPIN Q8TF76 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3141113 0.87 DAO (0.51) DAOHRH4DRD2DRD3MAPT
SCHEMBL4036292 0.86 DAO (0.50) DAOHRH4KDM5ADRD2DRD3
SCHEMBL1833251 0.76 KDM4E (0.55) DAOMAPTKDM4ESMN1; SMN2ALDH1A1
SCHEMBL29079881 0.75 DAO (0.49) DAOHRH4NR3C1PGRNR3C2
SCHEMBL1895337 0.75 DAO (0.58) DAOHRH4DRD2DRD3MAPT
SCHEMBL29414290 0.75 DAO (0.58) DAOHRH4DRD2DRD3MAPT
Hydrochloric Acid SCHEMBL29228902 0.73 DAO (0.56) DAOHRH4DRD2DRD3MAPT
SCHEMBL4033217 0.73 DAO (0.50) DAOHRH4DRD2DRD3MAPT
SCHEMBL3136216 0.73
SCHEMBL3137099 0.73 NR3C1 (0.34) NR3C1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1747220-B1 SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON AVENTIS PHARMA INC (US) 2009-04-15 EP claimed
EP-1599203-A1 1,3-SUBSTITUTED CYCLOALKYL DERIVATIVES CONTAINING ACIDIC, MAINLY HETEROCYCLIC GROUPS, CORRESPONDING PRODUCTION METHOD AND USE OF SAID DERIVATIVES AS MEDICAMENTS Sanofi-Aventis Deutschland GmbH (DE) 2005-11-30 EP disclosed
WO-2004075891-A1 1,3-SUBSTITUTED CYCLOALKYL DERIVATIVES CONTAINING ACIDIC, MAINLY HETEROCYCLIC GROUPS, CORRESPONDING PRODUCTION METHOD AND USE OF SAID DERIVATIVES AS MEDICAMENTS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-09-10 WO disclosed