Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 8/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036292 | 0.88 | DAO (0.50) | DAOHRH4CDK5DYRK1ACLK1 | |
| SCHEMBL3141113 | 0.86 | DAO (0.51) | DAOPDE3BPDE3AHRH4CNR2 | |
| SCHEMBL28761709 | 0.84 | DAO (0.50) | DAOPDE3BPDE3AHRH4CNR2 | |
| SCHEMBL3836490 | 0.77 | FLT3 (0.50) | DAOMAPTFGFR1 | |
| SCHEMBL157702 | 0.76 | HRH4 (0.56) | DAOPDE3BPDE3AHRH4CNR2 | |
| SCHEMBL29079873 | 0.74 | DAO (0.49) | DAOPDE3BPDE3AHRH4CNR2 | |
| SCHEMBL4038601 | 0.73 | DAO (0.51) | DAOPDE3BPDE3AHRH4DRD2 | |
| SCHEMBL29056767 | 0.73 | FLT3 (0.47) | HRH4KDRHDAC1 | |
| SCHEMBL1207759 | 0.72 | DAO (0.62) | DAOPDE3BPDE3AHRH4CNR2 | |
| SCHEMBL168527 | 0.70 | DAO (0.58) | DAOPDE3BPDE3AHRH4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |