Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 8/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.66 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.66 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 4/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | XDH | P47989 | 4/20 | 0.66 |
| ▸ | IPMK | Q8NFU5 | 4/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.66 |
| ▸ | IP6K2 | Q9UHH9 | 4/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036338 | 1.00 | POLH (0.66) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| SCHEMBL29904992 | 0.81 | POLH (0.71) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL28256564 | 0.79 | POLH (1.00) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL29352380 | 0.79 | POLH (1.00) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL20426 | 0.79 | POLH (1.00) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL29376494 | 0.79 | POLH (1.00) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL30045580 | 0.79 | POLH (1.00) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL31539190 | 0.78 | POLH (0.97) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL1659262 | 0.78 | POLH (0.97) | POLHMEN1KMT2ACYP1A2CYP1A1 | |
| Luteolin SCHEMBL31542150 | 0.78 | POLH (0.97) | POLHMEN1KMT2ACYP1A2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615906-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2006-01-18 | — | — | EP | claimed |
| WO-2004092154-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-10-28 | — | — | WO | claimed |
| US-20040198750-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-07 | — | — | US | claimed |
| US-7547794-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-16 | — | — | US | disclosed |
| EP-1615906-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092154-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040198750-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198750-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, MAP3K6, PACSIN2 | POLH 1214/4885MEN1 1272/4885KMT2A 1731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.