Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | MMP14 | P50281 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034449 | 0.87 | NPC1 (0.52) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL6051170 | 0.85 | KDM4E (0.77) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL8345688 | 0.81 | HSP90AA1 (0.60) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL4040116 | 0.80 | KDM4E (0.64) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL8344674 | 0.80 | KDM4E (0.56) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL4044274 | 0.80 | L3MBTL1 (0.43) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL8344672 | 0.78 | TP53 (0.54) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL8345105 | 0.78 | KDM4E (0.60) | KMT2AMEN1HTTSMN1; SMN2KDM4E | |
| SCHEMBL18586710 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2KDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL29587886 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2KDM4EMAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | claimed |
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | disclosed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |