SCHEMBL4036847

SCHEMBL4036847

CC(C)(C)OC(=O)On1nc(N)c2cc(CNC(=O)c3cccc(Cl)c3)ccc21

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
MEN1 O00255 1/20 0.43
HPGD P15428 1/20 0.43
TSHR P16473 1/20 0.43
KMT2A Q03164 1/20 0.43
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
ROCK2 O75116 2/20 0.40
NPC1 O15118 1/20 0.40
HDAC1 Q13547 1/20 0.40
BRD4 O60885 2/20 0.40
IDO1 P14902 2/20 0.40
ADORA2A P29274 1/20 0.40
THRB P10828 1/20 0.39
MAPK8 P45983 1/20 0.39
CHRM3 P20309 1/20 0.39
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL923468 0.86 CA1 (0.45) CA1CA2MEN1HPGDTSHR
SCHEMBL4035945 0.78 NR1H2 (0.38) HPGDALDH1A1
SCHEMBL3933572 0.73 ROCK2 (0.49) MEN1KMT2AALDH1A1LMNAROCK2
SCHEMBL3933114 0.73 NR1H2 (0.36) BRD4
SCHEMBL3927570 0.70 RAB9A (0.38) MEN1KMT2AALDH1A1NPC1IDO1
SCHEMBL4039865 0.70 JAK2 (0.67) CA1CA2MEN1HPGDTSHR
Hydrochloric Acid SCHEMBL923474 0.69 JAK2 (0.65) CA1CA2MEN1HPGDTSHR
SCHEMBL4212522 0.69 GUCY1A1 (0.36) KCNH2
SCHEMBL12907336 0.68 JAK2 (0.41) MEN1KMT2ALMNA
SCHEMBL3935784 0.68 KMT2A (0.40) KMT2AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230407419-A1 Rapid Diagnostic Test for LAMP NEW ENGLAND BIOLABS, INC. (US) 2023-12-21 US disclosed
US-11732315-B2 Rapid diagnostic test for lamp NEW ENGLAND BIOLABS, INC. (US) 2023-08-22 US disclosed
US-20230048863-A1 Rapid Diagnostic Test for LAMP NEW ENGLAND BIOLABS, INC. (US) 2023-02-16 US disclosed
EP-4118233-A1 A RAPID DIAGNOSTIC TEST FOR LAMP New England Biolabs, Inc. (US) 2023-01-18 EP disclosed
US-11525166-B2 Rapid diagnostic test for LAMP NEW ENGLAND BIOLABS, INC. (US) 2022-12-13 US disclosed
US-11345970-B2 Rapid diagnostic test for LAMP NEW ENGLAND BIOLABS, INC. (US) 2022-05-31 US disclosed
US-20210404024-A1 Rapid Diagnostic Test for LAMP NEW ENGLAND BIOLABS, INC. (US) 2021-12-30 US disclosed
WO-2021183921-A1 A RAPID DIAGNOSTIC TEST FOR LAMP NEW ENGLAND BIOLABS, INC. (US) 2021-09-16 WO disclosed
EP-2063869-A2 SOFT CHEWABLE, TABLET, AND LONG-ACTING INJECTABLE VETERINARY ANTIBIOTIC FORMULATIONS Merial Ltd. (US) 2009-06-03 EP disclosed
EP-1765788-B1 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES MERCK PATENT GMBH (DE) 2009-06-03 EP disclosed
US-20080160067-A1 Novel soft chewable, tablet, and long-acting injectable veterinary antibiotic formulations MERIAL LIMITED 2008-07-03 US disclosed
EP-1931417-A2 TRANSDERMAL DRUG DELIVERY SYSTEMS, DEVICES, AND METHODS EMPLOYING NOVEL PHARMACEUTICAL VEHICLES TRANSCUTANEOUS TECHNOLOGIES INC. (JP) 2008-06-18 EP disclosed
WO-2008030469-A2 SOFT CHEWABLE, TABLET, AND LONG-ACTING INJECTABLE VETERINARY ANTIBIOTIC FORMULATIONS MERIAL LIMITED (US) 2008-03-13 WO disclosed
US-20070083186-A1 Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles TTI ELLEBEAU, INC. (JP) 2007-04-12 US disclosed
WO-2007041314-A2 TRANSDERMAL DRUG DELIVERY SYSTEMS, DEVICES, AND METHODS EMPLOYING NOVEL PHARMACEUTICAL VEHICLES TTI ELLEBEAU, INC. (JP) 2007-04-12 WO disclosed
EP-1765788-A2 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES MERCK PATENT GmbH (DE) 2007-03-28 EP disclosed
WO-2005123688-A2 3-AMINOINDAZOLES MERCK PATENT GMBH (DE) 2005-12-29 WO disclosed