Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 6/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119234 | 0.87 | KMT2A (0.41) | KMT2ANAMPTPKMMAPK1RAB9A | |
| SCHEMBL3927570 | 0.82 | RAB9A (0.38) | KMT2ANAMPTPKMMAPK1RAB9A | |
| SCHEMBL3933572 | 0.80 | ROCK2 (0.49) | KMT2ANAMPTRAB9A | |
| SCHEMBL3933114 | 0.72 | NR1H2 (0.36) | AURKA | |
| SCHEMBL4041104 | 0.72 | ANO1 (0.44) | ANO1 | |
| SCHEMBL4134609 | 0.72 | RAB9A (0.39) | KMT2ANAMPTPKMMAPK1RAB9A | |
| SCHEMBL16564357 | 0.72 | JAK2 (0.49) | NAMPTMAPK1AURKAAURKB | |
| SCHEMBL4035945 | 0.71 | NR1H2 (0.38) | — | |
| SCHEMBL4212522 | 0.68 | GUCY1A1 (0.36) | GPR119GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL4036847 | 0.68 | CA1 (0.44) | KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040701-B1 | AMINOINDAZOLE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-03-18 | — | — | EP | disclosed |
| EP-2040701-A2 | AMINOINDAZOLE UREA DERIVATIVES | Merck Patent GmbH (DE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008009335-A2 | AMINOINDAZOLE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-01-24 | — | — | WO | disclosed |