Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933114 | 0.85 | NR1H2 (0.36) | NR1H2PDGFRACDK5TYRO3MAP2K4 | |
| SCHEMBL924609 | 0.81 | NR1H2 (0.44) | NR1H2PDGFRACDK5TYRO3MAP2K4 | |
| SCHEMBL4212522 | 0.80 | GUCY1A1 (0.36) | NR1H2PDGFRACDK5TYRO3 | |
| SCHEMBL4036847 | 0.78 | CA1 (0.44) | ALDH1A1HPGD | |
| SCHEMBL4041104 | 0.74 | ANO1 (0.44) | RIPK1 | |
| SCHEMBL3933572 | 0.72 | ROCK2 (0.49) | ROCK1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL3935784 | 0.71 | KMT2A (0.40) | — | |
| SCHEMBL16756072 | 0.66 | NR1H2 (0.52) | NR1H2 | |
| SCHEMBL2863260 | 0.66 | MAP2K4 (0.58) | NR1H2MAP2K4MAPT | |
| SCHEMBL25026048 | 0.65 | HTR6 (0.43) | NR1H2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| EP-1765788-A2 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GmbH (DE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123688-A2 | 3-AMINOINDAZOLES | MERCK PATENT GMBH (DE) | 2005-12-29 | — | — | WO | disclosed |