Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 8/20 | 0.40 |
| ▸ | FABP3 | P05413 | 3/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131960 | 0.90 | KDM4E (0.46) | KDM4EALDH1A1MAPTMEN1TP53 | |
| SCHEMBL14848072 | 0.85 | NPC1 (0.41) | FABP4FABP3FABP5KDM4EALDH1A1 | |
| SCHEMBL1332988 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1MAPTKMT2APOLB | |
| SCHEMBL31435276 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1MAPTKMT2APOLB | |
| SCHEMBL1009498 | 0.79 | TSHR (0.48) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1011786 | 0.79 | DHODH (0.45) | KDM4EALDH1A1MAPTKMT2APOLB | |
| SCHEMBL6131949 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1MAPTMEN1TP53 | |
| SCHEMBL9899016 | 0.78 | NR4A2 (0.50) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9899201 | 0.77 | NR4A2 (0.46) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3151462 | 0.76 | MAPK8 (0.47) | ALDH1A1MEN1KMT2AGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558603-B1 | OXYGE-CONTAINING HETEROCYCLIC FUSED NAPHTHOPYRANS | INSIGHT EQUITY A P X LP (US) | 2015-07-22 | — | — | EP | disclosed |
| EP-2578589-A1 | Oxygen-containing heterocyclic fused naphthopyrans having photochromic properties | Insight Equity A.P.X., LP (US) | 2013-04-10 | — | — | EP | disclosed |
| EP-1558603-A4 | OXYGE-CONTAINING HETEROCYCLIC FUSED NAPHTHOPYRANS | INSIGHT EQUITY A P X LP (US) | 2009-03-18 | — | — | EP | disclosed |
| US-7074943-B2 | Oxygen-containing heterocyclic fused naphthopyrans | VISION-EASE LENS (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1446406-B1 | PHOTOCHROMIC NAPHTHOPYRANS FOR OPHTHALMIC ARTICLES | VISION EASE LENS INC (US) | 2006-03-29 | — | — | EP | disclosed |
| US-7008568-B2 | Photochromic naphthopyran compounds: compositions and articles containing those naphthopyran compounds | VISION-EASE LENS, INC. (US) | 2006-03-07 | — | — | US | disclosed |
| US-20060030673-A1 | Oxygen-containing heterocyclic fused naphthopyrans | HOYA OPTICAL LABS OF AMERICA, INC. | 2006-02-09 | — | — | US | disclosed |
| US-6963003-B2 | Oxygen-containing heterocyclic fused naphthopyrans | VISION-EASE LANE (US) | 2005-11-08 | — | — | US | disclosed |
| EP-1558603-A2 | OXYGE-CONTAINING HETEROCYCLIC FUSED NAPHTHOPYRANS | Vision-Ease Lens, Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040215024-A1 | Oxygen-containing heterocyclic fused naphthopyrans | VISION-EASE LENS, INC. | 2004-10-28 | — | — | US | disclosed |
| EP-1446406-A2 | PHOTOCHROMIC NAPHTHOPYRANS FOR OPHTHALMIC ARTICLES | Vision-Ease Lens, Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2004047674-A2 | OXYGE-CONTAINING HETEROCYCLIC FUSED NAPHTHOPYRANS | VISION-EASE LENS, INC. (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20030146419-A1 | Photochromic naphthopyran compounds: compositions and articles containing those naphthopyran compounds | VISION-EASE LENS, INC. | 2003-08-07 | — | — | US | disclosed |
| WO-2003044022-A2 | PHOTOCHROMIC NAPHTHOPYRAN FOR OPHTHALMIC ARTICLES | VISION-EASE LENS, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030673-A1 | Oxygen-containing heterocyclic fused naphthopyrans | NQO1, NFE2L2, NDUFV2 | FABP4 2826/4885FABP3 3945/4885FABP5 1992/4885 |
| US-20040215024-A1 | Oxygen-containing heterocyclic fused naphthopyrans | NQO1, NFE2L2, NDUFV2 | FABP4 2896/4885FABP3 3917/4885FABP5 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.