Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8678271 | 0.83 | ESR2 (0.56) | KDM4ESYKAURKBINCENPGAA | |
| Hydrochloric Acid SCHEMBL5904242 | 0.80 | KMT2A (0.53) | ALDH1A1HPGDKDM4ESYKAURKB | |
| SCHEMBL3944878 | 0.79 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4ERAB9AALOX5 | |
| SCHEMBL8592649 | 0.79 | KDM4E (0.46) | ALDH1A1HPGDKDM4ERAB9AGAA | |
| SCHEMBL20124614 | 0.79 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4ERAB9ASYK | |
| Dimethylamine SCHEMBL5358041 | 0.77 | KMT2A (0.50) | ALDH1A1HPGDKDM4ESYKAURKB | |
| SCHEMBL9356023 | 0.77 | KDM4E (0.54) | ALDH1A1HPGDKDM4ERAB9ALMNA | |
| SCHEMBL15832030 | 0.76 | SYK (0.48) | ALDH1A1HPGDKDM4ERAB9ASYK | |
| Dimethylamine SCHEMBL9695311 | 0.76 | KMT2A (0.49) | ALDH1A1HPGDKDM4ESYKAURKB | |
| SCHEMBL15832020 | 0.76 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ERAB9ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
| WO-2009022171-A1 | PYRIDINYIIOXY PYRIDINES AS ALK5 INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | TGFBR1, TGFBR2, SMAD3 | ALDH1A1 163/4885HPGD 2761/4885KDM4E 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.