Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TAS2R31 | P59538 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048956 | 0.82 | CYP19A1 (0.67) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL31452750 | 0.78 | TAS2R31 (0.62) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL13596943 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1ABCB1MEN1MAPT | |
| SCHEMBL4040300 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1ABCB1MEN1MAPT | |
| SCHEMBL10425231 | 0.75 | ABCG2 (0.70) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL8064374 | 0.75 | CYP19A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL16894615 | 0.75 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL31322130 | 0.75 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL4050327 | 0.74 | ABCG2 (0.50) | KDM4EALDH1A1HPGDHSD17B10ABCG2 | |
| SCHEMBL5084370 | 0.73 | CYP1A1 (0.77) | KDM4EALDH1A1HPGDHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638554-B2 | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2009-12-29 | — | — | US | disclosed |
| US-7638554-B2 | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2009-12-29 | — | — | US | disclosed |
| US-7638554-B2 | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2009-12-29 | — | — | US | disclosed |
| EP-1495014-B1 | FLAVANOIDS DERIVATIVES AS CHEMOTHERAPEUTIC, CHEMOPREVENTIVE, AND ANTIANGIOGENIC AGENTS | STANFORD RES INST INT (US) | 2009-07-29 | — | — | EP | disclosed |
| US-7329687-B2 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329687-B2 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329687-B2 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2008-02-12 | — | — | US | disclosed |
| US-20060264500-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL (US) | 2006-11-23 | — | — | US | disclosed |
| EP-1495014-A2 | NOVEL FLAVANOIDS AND CHALCONES AS CHEMOTHERAPEUTIC, CHEMOPREVENTIVE, AND ANTIANGIOGENIC AGENTS | Sri International (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20040029914-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL | 2004-02-12 | — | — | US | disclosed |
| US-20030229136-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | SRI INTERNATIONAL | 2003-12-11 | — | — | US | disclosed |
| WO-2003089423-A2 | NOVEL FLAVANOIDS AND CHALCONES AS CHEMOTHERAPEUTIC, CHEMOPREVENTIVE, AND ANTIANGIOGENIC AGENTS | SRI INTERNATIONAL (US) | 2003-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264500-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | FLT1, CCNE1, CCNA1 | KDM4E 1979/4885ALDH1A1 229/4885HPGD 245/4885 |
| US-20040029914-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | FLT1, VEGFA, FLT4 | KDM4E 1122/4885ALDH1A1 175/4885HPGD 224/4885 |
| US-20030229136-A1 | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents | FLT1, VEGFA, FLT4 | KDM4E 1314/4885ALDH1A1 154/4885HPGD 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.