Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3484397 | 0.85 | FFAR4 (0.41) | HTTTDP1L3MBTL1FFAR4FFAR1 | |
| SCHEMBL27347338 | 0.79 | SLC22A12 (0.43) | TDP1SMN1; SMN2PPARASLC22A12 | |
| SCHEMBL4040746 | 0.75 | PPARG (0.55) | HTTTDP1L3MBTL1FFAR4FFAR1 | |
| SCHEMBL13047065 | 0.74 | HTT (0.50) | HTTTDP1L3MBTL1FFAR4FFAR1 | |
| SCHEMBL3381395 | 0.72 | CA12 (0.41) | SMN1; SMN2CYP1A2HSD17B1HSD17B2PPARA | |
| SCHEMBL11538993 | 0.72 | PPARA (0.51) | CYP1A2CYP2C19PPARAALDH1A1SLC22A12 | |
| SCHEMBL2867826 | 0.71 | AKR1C3 (0.77) | HTTTDP1L3MBTL1CYP2C9NPC1 | |
| SCHEMBL15085780 | 0.71 | SMN1; SMN2 (0.60) | HTTTDP1L3MBTL1FFAR4FFAR1 | |
| SCHEMBL3150010 | 0.71 | SLC22A12 (0.50) | FFAR1PPARAALDH1A1SLC22A12 | |
| Bicarbonate SCHEMBL1886282 | 0.71 | SMN1; SMN2 (0.66) | HTTTDP1FFAR1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049107-A2 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES | Genfit (FR) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008012470-A2 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES | GENFIT (FR) | 2008-01-31 | — | — | WO | disclosed |