SCHEMBL4038005

SCHEMBL4038005

COc1cccc(C2(C(CCc3ccccc3)C(=O)NC(C)C)Nc3ccccc3N2)c1OC

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
KMT2A Q03164 4/20 0.40
CTSG P08311 1/20 0.39
CMA1 P23946 1/20 0.39
BCHE P06276 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 2/20 0.38
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
G6PD P11413 1/20 0.38
KDM4E B2RXH2 1/20 0.38
TAAR1 Q96RJ0 1/20 0.37
NPC1 O15118 2/20 0.37
PTGES O14684 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4036682 0.86 METAP2 (0.44) HPGDALDH1A1L3MBTL1
SCHEMBL4044794 0.84 MEN1 (0.51) ALDH1A1KMT2AL3MBTL1MEN1TAS1R3
SCHEMBL4039856 0.80 HPGD (0.44) HPGDALDH1A1KMT2AMEN1TAAR1
SCHEMBL4038935 0.79 METAP2 (0.43) HPGDALDH1A1KMT2AMEN1KDM4E
SCHEMBL16569002 0.77 HPGD (0.38) HPGDALDH1A1LMNAKMT2AL3MBTL1
SCHEMBL4035018 0.77 ACE (0.41) HPGDALDH1A1LMNAKMT2AMEN1
SCHEMBL4038175 0.77 METAP2 (0.37) HPGDALDH1A1L3MBTL1TAS1R3TAS1R1
SCHEMBL4039555 0.76 USP2 (0.38) ALDH1A1LMNAKMT2AL3MBTL1MEN1
SCHEMBL4038962 0.75 MASP2 (0.42) HPGDALDH1A1LMNAKMT2AL3MBTL1
SCHEMBL4041615 0.74 CNR1 (0.41) ALDH1A1LMNACTSGCMA1PTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed