SCHEMBL4041615

SCHEMBL4041615

CC(C)NC(=O)C(CCc1ccccc1)C1(c2cccc(C#N)c2)Nc2ccccc2N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 4/20 0.41
CNR2 P34972 3/20 0.41
MMP12 P39900 1/20 0.40
MMP13 P45452 1/20 0.40
PRSS1 P07477 1/20 0.39
CTSG P08311 1/20 0.39
CTRB1 P17538 1/20 0.39
CMA1 P23946 1/20 0.39
LMNA P02545 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CTSC P53634 1/20 0.37
FOLH1 Q04609 1/20 0.37
PTGES O14684 1/20 0.36
BACE1 P56817 1/20 0.36
GPR139 Q6DWJ6 1/20 0.36
TSHR P16473 1/20 0.36
POLB P06746 1/20 0.36
PKM P14618 1/20 0.36
OPRM1 P35372 1/20 0.36
ARRB1 P49407 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4038962 0.88 MASP2 (0.42) CNR1CNR2LMNAALDH1A1PTGES
SCHEMBL4044238 0.85 CTSD (0.42) ALDH1A1BACE1TSHR
SCHEMBL4035018 0.81 ACE (0.41) LMNAALDH1A1TSHRPOLBOPRM1
SCHEMBL4038005 0.74 HPGD (0.41) CTSGCMA1LMNAALDH1A1PTGES
SCHEMBL4037580 0.73 TSHR (0.40) CNR2ALDH1A1BACE1TSHRPOLB
SCHEMBL4044794 0.73 MEN1 (0.51) ALDH1A1POLB
SCHEMBL13257646 0.68 HPGD (0.69) LMNAALDH1A1GPR139POLB
SCHEMBL13257659 0.68 HPGD (0.69) LMNAALDH1A1GPR139POLB
SCHEMBL19249056 0.65 CNR1 (0.54) CNR1CNR2LMNAALDH1A1FOLH1
SCHEMBL4039856 0.63 HPGD (0.44) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed