Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.60 |
| ▸ | MMP1 | P03956 | 4/20 | 0.60 |
| ▸ | MMP3 | P08254 | 2/20 | 0.60 |
| ▸ | MMP7 | P09237 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 4/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 3/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036361 | 1.00 | MMP9 (0.60) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL4037002 | 0.93 | MMP1 (0.62) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL4035557 | 0.93 | MMP1 (0.62) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL4038681 | 0.93 | MMP1 (0.62) | MMP9MMP1MMP3MMP7MMP13 | |
| Hydroxyamine SCHEMBL6273391 | 0.89 | MMP3 (0.56) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL12659053 | 0.89 | MMP1 (0.62) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL2441360 | 0.88 | MMP1 (0.64) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL4039362 | 0.86 | MMP1 (0.52) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL2445821 | 0.86 | MMP1 (0.59) | MMP9MMP1MMP3MMP7MMP13 | |
| SCHEMBL2439382 | 0.86 | MMP1 (0.59) | MMP9MMP1MMP3MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404690-B2 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2013-03-26 | — | — | US | disclosed |
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | disclosed |
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | P2RX5, P2RX2, NPY5R | MMP9 4189/4885MMP1 3474/4885MMP3 2393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.