Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.49 |
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044346 | 0.88 | EPHX1 (0.47) | EPHX1METAP2METAP1POLBKMT2A | |
| SCHEMBL4035092 | 0.75 | HPGD (0.44) | EPHX1METAP2METAP1KMT2ASMN1; SMN2 | |
| SCHEMBL4042729 | 0.72 | HPGD (0.44) | EPHX1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4036690 | 0.72 | TSHR (0.43) | POLBKMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4039455 | 0.71 | KMT2A (0.48) | POLBKMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4039869 | 0.71 | HPGD (0.45) | KMT2AHPGDLMNAL3MBTL1MEN1 | |
| SCHEMBL4044888 | 0.71 | KMT2A (0.45) | POLBKMT2ASMN1; SMN2MEN1KDM4E | |
| SCHEMBL4044962 | 0.71 | KMT2A (0.49) | EPHX1KMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL4043366 | 0.71 | TSHR (0.50) | POLBKMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL4044367 | 0.70 | PKM (0.40) | EPHX1POLBKMT2ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |