Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.96 |
| ▸ | TP53 | P04637 | 4/20 | 0.96 |
| ▸ | HPGD | P15428 | 4/20 | 0.96 |
| ▸ | MAPT | P10636 | 4/20 | 0.96 |
| ▸ | TSHR | P16473 | 3/20 | 0.96 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.96 |
| ▸ | CASP1 | P29466 | 1/20 | 0.96 |
| ▸ | CASP7 | P55210 | 1/20 | 0.96 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | STAT1 | P42224 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | CTSL | P07711 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14982108 | 0.91 | NPC1 (0.82) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL2975193 | 0.91 | NPC1 (0.82) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL24620616 | 0.89 | NPC1 (0.85) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL2064358 | 0.84 | NPC1 (0.71) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL12799147 | 0.84 | NPC1 (0.71) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL2742812 | 0.84 | NPC1 (0.96) | NPC1RAB9AALDH1A1TP53HPGD | |
| Hydrochloric Acid SCHEMBL2159983 | 0.82 | NPC1 (0.69) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL1821338 | 0.82 | ALDH1A1 (0.70) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL14982061 | 0.81 | NPC1 (1.00) | NPC1RAB9AALDH1A1TP53HPGD | |
| SCHEMBL3142490 | 0.81 | RAB9A (1.00) | NPC1RAB9AALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966180-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2015-02-18 | — | — | EP | disclosed |
| US-7527754-B2 | Photochromic indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| EP-1966180-A1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007078529-A1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2007-07-12 | — | — | WO | disclosed |
| US-20070138448-A1 | Photochromic indeno-fused naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070138448-A1 | Photochromic indeno-fused naphthopyrans | INTS6, IPO4, NQO1 | NPC1 2582/4885RAB9A 4170/4885ALDH1A1 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.