Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699832 | 0.84 | ALDH1A1 (0.48) | KMT2AMEN1CHRM2CHRM3PKLR | |
| SCHEMBL2703917 | 0.83 | CYP3A4 (0.63) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2702729 | 0.82 | CHRM2 (0.59) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2701101 | 0.82 | GABRD (0.51) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2702453 | 0.79 | CHRM2 (0.66) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2702731 | 0.78 | L3MBTL1 (0.60) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3420497 | 0.77 | KDM4E (0.55) | KMT2AMEN1ALDH1A1LMNANAMPT | |
| SCHEMBL2701104 | 0.77 | L3MBTL1 (0.46) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL21212527 | 0.77 | PROKR1 (0.51) | CYP3A4CYP2D6CYP2C19TSHRPKLR | |
| SCHEMBL2700039 | 0.77 | PKLR (0.57) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582654-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-01 | — | — | US | disclosed |
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | LLOYD JOHN | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | KCNJ2, KCNH2, KCNQ5 | KMT2A 957/4885MEN1 3501/4885CYP3A4 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.