Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 9/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.59 |
| ▸ | TLK2 | Q86UE8 | 5/20 | 0.59 |
| ▸ | RET | P07949 | 4/20 | 0.59 |
| ▸ | FLT3 | P36888 | 3/20 | 0.59 |
| ▸ | JAK3 | P52333 | 3/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10095156 | 0.85 | PDPK1 (0.63) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL32676572 | 0.76 | PDPK1 (0.74) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL32676535 | 0.76 | PDPK1 (0.74) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL32676559 | 0.76 | PDPK1 (0.74) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL29385385 | 0.75 | PDPK1 (1.00) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL13038796 | 0.75 | PDPK1 (1.00) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL30898303 | 0.75 | PDPK1 (1.00) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL1162655 | 0.75 | PDPK1 (1.00) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL30898301 | 0.75 | PDPK1 (1.00) | PDPK1KDRPDGFRBTLK2RET | |
| SCHEMBL1162656 | 0.75 | PDPK1 (1.00) | PDPK1KDRPDGFRBTLK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305026-B1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | NOVUSPHARMA SPA (IT) | 2009-05-13 | — | — | EP | disclosed |
| EP-1305026-B1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | NOVUSPHARMA SPA (IT) | 2009-05-13 | — | — | EP | disclosed |
| US-20080113993-A1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | VIA ARIOSTO, 23 (IT) | 2008-05-15 | — | — | US | disclosed |
| US-20080113993-A1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | VIA ARIOSTO, 23 (IT) | 2008-05-15 | — | — | US | disclosed |
| US-20080113993-A1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | VIA ARIOSTO, 23 (IT) | 2008-05-15 | — | — | US | disclosed |
| US-20030229108-A1 | Barbituric acid analogs as therapeutic agents | NOVUSPHARMA S.P.A. (IT) | 2003-12-11 | — | — | US | disclosed |
| EP-1305026-A2 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | Novuspharma S.p.A. (IT) | 2003-05-02 | — | — | EP | disclosed |
| WO-2001093841-A2 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | NOVUSPHARMA S.P.A. (IT) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229108-A1 | Barbituric acid analogs as therapeutic agents | HIF1AN, HIF1A, VHL | PDPK1 1276/4885KDR 214/4885PDGFRB 178/4885 |
| US-20080113993-A1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | HIF1A, HIF1AN, PDGFA | PDPK1 1342/4885KDR 295/4885PDGFRB 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.