Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 5/20 | 0.44 |
| ▸ | SRC | P12931 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982709 | 0.88 | LCK (0.53) | FGFR1KDRLCKPIK3CDWEE1 | |
| SCHEMBL7979955 | 0.86 | LCK (0.54) | FGFR1KDRLCK | |
| SCHEMBL7981128 | 0.83 | LCK (0.54) | FGFR1KDRLCKSRCPIK3CD | |
| SCHEMBL4041225 | 0.82 | FGFR1 (0.51) | FGFR1KDRLCKSRCEGFR | |
| SCHEMBL7982930 | 0.82 | LCK (0.51) | FGFR1KDRLCKSRCWEE1 | |
| SCHEMBL7983214 | 0.81 | LCK (0.51) | FGFR1KDRLCKSRCEGFR | |
| SCHEMBL7979828 | 0.79 | LCK (0.48) | FGFR1KDRLCK | |
| SCHEMBL7983693 | 0.77 | LCK (0.43) | FGFR1KDRLCKSRCEGFR | |
| SCHEMBL7969762 | 0.76 | LCK (0.46) | FGFR1LCKSRC | |
| SCHEMBL7987014 | 0.76 | LCK (0.45) | FGFR1KDRLCKSRCWEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |