Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983002 | 0.91 | LCK (0.46) | LCKPDE2ASRCFGFR1TLR7 | |
| SCHEMBL7981250 | 0.86 | PDE2A (0.40) | LCKPDE2ASRCFGFR1PDE10A | |
| SCHEMBL7981389 | 0.84 | FGFR1 (0.41) | LCKPDE2ASRCFGFR1PDE10A | |
| SCHEMBL7983693 | 0.84 | LCK (0.43) | LCKPDE2ASRCFGFR1TLR7 | |
| SCHEMBL7983712 | 0.82 | PDE2A (0.39) | LCKPDE2ASRCFGFR1PDE10A | |
| SCHEMBL7981780 | 0.81 | NPC1 (0.43) | PDE2AFGFR1ALDH1A1KDM4EMEN1 | |
| SCHEMBL7982709 | 0.80 | LCK (0.53) | LCKPDE2AFGFR1 | |
| SCHEMBL7983558 | 0.80 | LCK (0.39) | LCKPDE2ASRCFGFR1TLR7 | |
| SCHEMBL7981128 | 0.78 | LCK (0.54) | LCKSRCFGFR1KMT2A | |
| SCHEMBL7982930 | 0.78 | LCK (0.51) | LCKPDE2ASRCFGFR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |