Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | KAT7 | O95251 | 1/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036178 | 0.93 | KIF11 (0.46) | HTR6BCHEKIF11KIF23GPR119 | |
| SCHEMBL5899029 | 0.77 | KIF11 (0.47) | KIF11KIF23BRD4 | |
| SCHEMBL4046310 | 0.72 | KIF11 (0.53) | KIF11KIF23 | |
| SCHEMBL27406174 | 0.68 | ACKR3 (0.54) | HTR6BCHEACKR3KDM1AFEN1 | |
| SCHEMBL6214983 | 0.67 | ACKR3 (0.57) | HTR6BCHEACKR3KDM1AGPR119 | |
| SCHEMBL8237687 | 0.67 | ACKR3 (0.57) | HTR6BCHEACKR3KDM1AGPR119 | |
| SCHEMBL5871116 | 0.66 | ACKR3 (0.67) | HTR6BCHEACKR3KDM1AGPR119 | |
| SCHEMBL5870792 | 0.66 | ACKR3 (0.67) | HTR6BCHEACKR3KDM1AGPR119 | |
| SCHEMBL2959964 | 0.66 | HTR6 (0.54) | HTR6BCHEACKR3KDM1AGPR119 | |
| SCHEMBL2959968 | 0.66 | HTR6 (0.54) | HTR6BCHEACKR3KDM1AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-B1 | FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | EP | disclosed |