Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841917 | 0.93 | LMNA (0.39) | LMNAPTGER3TP53L3MBTL1TDP1 | |
| SCHEMBL4035782 | 0.84 | PKM (0.39) | LMNATP53L3MBTL1ATMKMT2A | |
| SCHEMBL4030551 | 0.83 | LMNA (0.40) | LMNAPTGER3TP53L3MBTL1TDP1 | |
| SCHEMBL28798992 | 0.79 | LMNA (0.36) | LMNATDP1POLB | |
| SCHEMBL4842879 | 0.78 | LMNA (0.40) | LMNAPTGER3TP53L3MBTL1TDP1 | |
| SCHEMBL4562101 | 0.77 | KMT2A (0.42) | LMNAPTGER3TP53L3MBTL1TDP1 | |
| SCHEMBL4844911 | 0.77 | MEN1 (0.46) | LMNAPTGER3RAB9AKMT2AALDH1A1 | |
| SCHEMBL4842372 | 0.75 | LMNA (0.48) | LMNAPTGER3KMT2AALDH1A1NPSR1 | |
| SCHEMBL4036300 | 0.74 | LMNA (0.50) | LMNAPTGER3TP53L3MBTL1TDP1 | |
| SCHEMBL4036560 | 0.74 | TRPA1 (0.45) | LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885695-B8 | INDOLINE COMPOUNDS | FOURNIER LAB SA (FR) | 2009-08-12 | — | — | EP | disclosed |
| EP-1885695-B1 | INDOLINE COMPOUNDS | FOURNIER LAB SA (FR) | 2009-02-25 | — | — | EP | disclosed |
| EP-1885695-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007000550-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2007-01-04 | — | — | WO | disclosed |