Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039335 | 0.80 | METAP2 (0.60) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL1811084 | 0.80 | HIF1A (0.49) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL4042845 | 0.79 | HIF1A (0.48) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL3822384 | 0.78 | HIF1A (0.64) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL1811826 | 0.78 | HIF1A (0.46) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL12622768 | 0.75 | HIF1A (0.46) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL12622766 | 0.75 | HIF1A (0.44) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL1815491 | 0.74 | HIF1A (0.46) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL4041268 | 0.73 | HTT (0.45) | HTTMAPTSMN1; SMN2HIF1ANPSR1 | |
| SCHEMBL11653681 | 0.71 | DRD2 (0.58) | HTTMAPTLMNAALDH1A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |