Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.34 |
| ▸ | DRD1 | P21728 | 8/20 | 0.34 |
| ▸ | DRD3 | P35462 | 8/20 | 0.34 |
| ▸ | DRD2 | P14416 | 7/20 | 0.34 |
| ▸ | HRH1 | P35367 | 7/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.34 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4037401 | 0.99 | MEN1 (0.36) | MEN1KMT2AADRA2ADRD1DRD3 | |
| SCHEMBL4038879 | 0.94 | ADRA2A (0.38) | MEN1KMT2AADRA2ADRD1DRD3 | |
| SCHEMBL6331962 | 0.93 | KMT2A (0.38) | MEN1KMT2AADRA2ADRD1DRD3 | |
| Hydrochloric Acid SCHEMBL4036021 | 0.93 | ADRA2A (0.37) | MEN1KMT2AADRA2ADRD1DRD3 | |
| SCHEMBL4039594 | 0.90 | MEN1 (0.39) | MEN1KMT2AADRA2ADRD1DRD3 | |
| Hydrochloric Acid SCHEMBL4037809 | 0.89 | KMT2A (0.40) | MEN1KMT2AADRA2ADRD1DRD3 | |
| SCHEMBL6331870 | 0.88 | MEN1 (0.35) | MEN1KMT2AADRA2ADRD1DRD3 | |
| SCHEMBL4040369 | 0.88 | LMNA (0.48) | MEN1KMT2AADRA2ADRD1DRD3 | |
| SCHEMBL4043965 | 0.88 | KMT2A (0.35) | MEN1KMT2AADRA2ADRD1DRD3 | |
| Hydrochloric Acid SCHEMBL4041643 | 0.87 | LMNA (0.49) | MEN1KMT2AADRA2ADRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284977-B1 | THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-24 | — | — | EP | claimed |