Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | MMP7 | P09237 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039234 | 1.00 | MAPT (0.39) | MAPTKMT2ANPSR1MEN1HTT | |
| SCHEMBL4033158 | 1.00 | MAPT (0.39) | MAPTKMT2ANPSR1MEN1HTT | |
| SCHEMBL4037448 | 0.90 | MAPK1 (0.37) | MAPTKMT2ANPSR1MEN1HTT | |
| SCHEMBL4203707 | 0.86 | ALDH1A1 (0.42) | MAPTKMT2ANPSR1MEN1HTT | |
| SCHEMBL30600005 | 0.60 | MAPT (0.64) | MAPTKMT2AMEN1HTTHSD17B10 | |
| SCHEMBL15462055 | 0.58 | ALDH1A1 (0.58) | MAPTKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL2953594 | 0.57 | ALDH1A1 (0.76) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL1618681 | 0.57 | ALDH1A1 (0.56) | MAPTKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL5635019 | 0.56 | MAPT (0.39) | MAPTKMT2ANPSR1LMNAUSP2 | |
| SCHEMBL28522648 | 0.56 | LTA4H (0.60) | MAPTKMT2ANPSR1MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |