Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037687 | 0.80 | GAA (0.45) | MAPTALDH1A1KMT2ACYP3A4GAA | |
| SCHEMBL4036536 | 0.78 | MAPT (0.45) | MAPTNPSR1ALDH1A1CYP2D6KMT2A | |
| SCHEMBL4036561 | 0.68 | FAAH (0.38) | MAPTNPSR1KMT2ACA2 | |
| SCHEMBL4034457 | 0.68 | GAA (0.39) | MAPTNPSR1ALDH1A1KMT2AUSP2 | |
| SCHEMBL5635771 | 0.66 | OPRD1 (0.36) | NPSR1ALDH1A1CYP2D6KMT2ACYP3A4 | |
| SCHEMBL5624203 | 0.61 | KMT2A (0.70) | MAPTNPSR1ALDH1A1KMT2AUSP2 | |
| SCHEMBL3768575 | 0.61 | ALDH1A1 (0.63) | ALDH1A1CYP2D6KMT2AUSP2GAA | |
| SCHEMBL28400470 | 0.60 | MAPT (0.60) | MAPTNPSR1ALDH1A1CYP2D6KMT2A | |
| SCHEMBL1000444 | 0.60 | MAPT (0.64) | MAPTNPSR1ALDH1A1CYP2D6KMT2A | |
| SCHEMBL6744239 | 0.59 | ALDH1A1 (0.71) | ALDH1A1CYP2D6KMT2AUSP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2007-06-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | P2RX5, P2RX2, NPY5R | MAPT 4555/4885NPSR1 402/4885ALDH1A1 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.