Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040157 | 0.90 | MAPT (0.39) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL4039234 | 0.90 | MAPT (0.39) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL4033158 | 0.90 | MAPT (0.39) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL4203707 | 0.83 | ALDH1A1 (0.42) | MAPK1MAPTHTTMEN1KMT2A | |
| SCHEMBL29284985 | 0.58 | PKM (0.56) | MAPK1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL1383996 | 0.58 | PKM (0.46) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30600005 | 0.57 | MAPT (0.64) | MAPTHTTMEN1KMT2AHSD17B10 | |
| SCHEMBL3801000 | 0.56 | RAB9A (0.52) | HTTSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL3801002 | 0.56 | ALDH1A1 (0.55) | MEN1KMT2ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL1221581 | 0.56 | PKM (0.63) | HTTNPSR1SMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |