Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040633 | 0.93 | CTSK (0.48) | CTSKROCK2GFERDNMT3BAHR | |
| SCHEMBL4040649 | 0.90 | CTSK (0.42) | CTSKSMYD3ACEGPR132 | |
| SCHEMBL4044537 | 0.90 | CTSK (0.41) | CTSKKDM1AROCK2GFERAHR | |
| SCHEMBL4046752 | 0.89 | CTSK (0.40) | CTSKSMYD3ACEGPR132 | |
| SCHEMBL4048150 | 0.89 | CTSK (0.47) | CTSK | |
| SCHEMBL4045831 | 0.89 | CTSK (0.51) | CTSKSMYD3ACEGPR132KMT2A | |
| SCHEMBL4041827 | 0.89 | CTSK (0.43) | CTSKSMYD3ACEGPR132 | |
| SCHEMBL4040654 | 0.88 | CTSK (0.41) | CTSKKDM1AROCK2GFERDNMT3B | |
| SCHEMBL4038224 | 0.88 | CTSK (0.44) | CTSKSMYD3ACEGPR132 | |
| SCHEMBL4042752 | 0.88 | CTSK (0.52) | CTSKSMYD3ACEGPR132KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| US-20060100431-A1 | Biologically active compounds | AMURA THERAPEUTICS LIMITED (GB) | 2006-05-11 | — | — | US | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1853255-A4 | METHODS FOR TREATING ARTHRITIS USING TRIHETEROCYCLIC COMPOUNDS | GEMIN X PHARMACEUTICALS CANADA (CA) | 2009-07-08 | — | — | EP | disclosed |
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| EP-1853255-A1 | METHODS FOR TREATING ARTHRITIS USING TRIHETEROCYCLIC COMPOUNDS | Gemin X Biotechnologies Inc. (CA) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006089397-A1 | METHODS FOR TREATING ARTHRITIS USING TRIHETEROCYCLIC COMPOUNDS | GEMIN X BIOTECHNOLOGIES INC. (CA) | 2006-08-31 | — | — | WO | disclosed |
| US-20060100431-A1 | Biologically active compounds | AMURA THERAPEUTICS LIMITED (GB) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100431-A1 | Biologically active compounds | SOST, CTSK, CTSS | CTSK 2/4885KDM1A 3980/4885ROCK2 4215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.