Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041190 | 0.84 | LCK (0.51) | LCKFGFR1SRCALDH1A1TSHR | |
| SCHEMBL4038830 | 0.83 | LCK (0.49) | LCKFGFR1KDR | |
| SCHEMBL4041184 | 0.82 | LCK (0.55) | LCKFGFR1SRCKDRALDH1A1 | |
| SCHEMBL7983651 | 0.80 | LCK (0.59) | LCKFGFR1SRCALDH1A1TSHR | |
| SCHEMBL4041225 | 0.77 | FGFR1 (0.51) | LCKFGFR1SRCKDRCHRM1 | |
| SCHEMBL7984582 | 0.77 | LCK (0.61) | LCKSRCALDH1A1HSD17B10PDPK1 | |
| SCHEMBL7983212 | 0.75 | LCK (0.60) | LCKFGFR1SRCKDR | |
| SCHEMBL7983616 | 0.73 | LCK (0.51) | LCKFGFR1SRCALDH1A1TSHR | |
| SCHEMBL7982990 | 0.73 | LCK (0.55) | LCKFGFR1SRCKDRPDPK1 | |
| SCHEMBL7987022 | 0.72 | LCK (0.52) | LCKFGFR1SRCKDRPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |