Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL202283 | 0.90 | RAB9A (0.43) | KCNN4LMNAMAPTMAPK1HTT | |
| SCHEMBL3217833 | 0.82 | KCNN4 (0.47) | KCNN4ALDH1A1LMNAHTTUSP2 | |
| SCHEMBL11479898 | 0.78 | KCNN4 (0.43) | KCNN4ALDH1A1LMNAHTTUSP2 | |
| SCHEMBL3143169 | 0.77 | NFE2L2 (0.46) | ALDH1A1LMNARAB9AMAOBHSD11B1 | |
| SCHEMBL11485302 | 0.74 | KCNN4 (0.40) | KCNN4ALDH1A1LMNAKCNE1KCNQ1 | |
| SCHEMBL13149681 | 0.72 | MAPT (0.46) | KCNN4ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL13149708 | 0.72 | MAPT (0.46) | KCNN4ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL1958061 | 0.72 | NPC1 (0.53) | ALDH1A1LMNAMAPTMAPK1HTT | |
| SCHEMBL1817358 | 0.72 | SMN1; SMN2 (0.45) | ALDH1A1LMNATDP1MAOBCYP3A4 | |
| SCHEMBL18867937 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966180-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2015-02-18 | — | — | EP | disclosed |
| US-7527754-B2 | Photochromic indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| EP-1966180-A1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007078529-A1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2007-07-12 | — | — | WO | disclosed |
| US-20070138448-A1 | Photochromic indeno-fused naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070138448-A1 | Photochromic indeno-fused naphthopyrans | INTS6, IPO4, NQO1 | KCNN4 573/4885ALDH1A1 593/4885LMNA 1138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.