Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217833 | 0.92 | KCNN4 (0.47) | RAB9AUSP2CYP19A1KCNN4CYP3A4 | |
| SCHEMBL4041575 | 0.90 | KCNN4 (0.38) | RAB9AUSP2CYP19A1KCNN4CYP3A4 | |
| SCHEMBL11479898 | 0.87 | KCNN4 (0.43) | RAB9AUSP2KCNN4CYP3A4CYP2D6 | |
| SCHEMBL3143169 | 0.85 | NFE2L2 (0.46) | RAB9AHSD11B1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL11485302 | 0.82 | KCNN4 (0.40) | KCNN4KCNE1KCNQ1L3MBTL1LMNA | |
| SCHEMBL1817358 | 0.80 | SMN1; SMN2 (0.45) | CYP3A4CYP2D6CYP2C19SMN1; SMN2GAA | |
| SCHEMBL1958061 | 0.80 | NPC1 (0.53) | RAB9AUSP2HSD11B1HTTKMT2A | |
| SCHEMBL1962637 | 0.79 | AKR1C3 (0.49) | USP2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1959801 | 0.79 | FAAH (0.47) | CYP2D6CYP2C19SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL10049978 | 0.78 | ESR1 (0.44) | RAB9ACYP3A4KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227099-B | Articles comprising indolonaphthopyrans | 光学转变有限公司 | 2025-03-11 | — | — | CN | disclosed |
| US-12247035-B2 | Articles comprising indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2025-03-11 | — | — | US | disclosed |
| EP-3898635-B1 | ARTICLES COMPRISING INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2024-12-04 | — | — | EP | disclosed |
| US-11897894-B2 | Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2024-02-13 | — | — | US | disclosed |
| EP-3268375-B1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2022-06-15 | — | — | EP | disclosed |
| CN-107253943-B | Photochromic compounds and compositions | 光学转变公司 | 2022-05-17 | — | — | CN | disclosed |
| US-20220064175-A1 | Articles Comprising Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-03-03 | — | — | US | disclosed |
| EP-3898844-A1 | INDOLENAPHTHOPYRANS AND PHOTOCHROMIC COMPOSITIONS COMPRISING THEM | Transitions Optical, Ltd. (IE) | 2021-10-27 | — | — | EP | disclosed |
| EP-3898635-A1 | ARTICLES COMPRISING INDOLENAPHTHOPYRANS | Transitions Optical, Ltd. (IE) | 2021-10-27 | — | — | EP | disclosed |
| US-20210317129-A1 | Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2021-10-14 | — | — | US | disclosed |
| EP-2401269-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2012-01-04 | — | — | EP | disclosed |
| US-20110143141-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110129678-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20100234415-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-09-16 | — | — | US | disclosed |
| WO-2010099039-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-09-02 | — | — | WO | disclosed |
| EP-1963896-B1 | PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS | TRANSITIONS OPTICAL INC (US) | 2010-02-10 | — | — | EP | disclosed |
| US-7556751-B2 | Photochromic materials having electron-withdrawing substituents | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1963896-A1 | PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007073462-A1 | PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
| US-20070138449-A1 | Photochromic materials having electron-withdrawing substituents | TRANSITIONS OPTICAL LIMITED (IE) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110143141-A1 | Photochromic compounds and compositions | CCNA1, CRY1, CCNT1 | RAB9A 1829/4885USP2 3531/4885CYP19A1 138/4885 |
| US-20210317129-A1 | Indolenaphthopyrans | AHR, TDO2, TPH2 | RAB9A 2996/4885USP2 2952/4885CYP19A1 966/4885 |
| US-11897894-B2 | Indolenaphthopyrans | AHR, TDO2, TPH2 | RAB9A 2996/4885USP2 2952/4885CYP19A1 966/4885 |
| US-20100234415-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | PTGER2, PTGDR2, PTGDR | RAB9A 3377/4885USP2 2639/4885CYP19A1 875/4885 |
| US-20220064175-A1 | Articles Comprising Indolenaphthopyrans | CDC25B, ACTB, CCNB1 | RAB9A 1667/4885USP2 1455/4885CYP19A1 2214/4885 |
| US-20110129678-A1 | Photochromic compounds and compositions | CRY2, CRY1, PPOX | RAB9A 2888/4885USP2 3017/4885CYP19A1 1449/4885 |
| US-12247035-B2 | Articles comprising indolenaphthopyrans | ACTB, CCNB1, HMBS | RAB9A 2299/4885USP2 1222/4885CYP19A1 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.