Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052403 | 0.85 | METAP2 (0.36) | METAP2METAP1 | |
| SCHEMBL4053441 | 0.84 | ADORA3 (0.40) | METAP2METAP1 | |
| SCHEMBL4047518 | 0.84 | METAP2 (0.33) | METAP2METAP1 | |
| SCHEMBL4046994 | 0.78 | ADORA1 (0.42) | METAP2METAP1 | |
| SCHEMBL4047107 | 0.78 | PDE9A (0.35) | PDE9AMETAP2METAP1 | |
| SCHEMBL13905292 | 0.78 | PDE9A (0.35) | PDE9AMETAP2METAP1 | |
| SCHEMBL4052252 | 0.75 | KDM4C (0.41) | METAP2METAP1 | |
| SCHEMBL4046849 | 0.73 | METAP2 (0.35) | METAP2METAP1 | |
| SCHEMBL4051241 | 0.72 | PI4KA (0.45) | — | |
| SCHEMBL4048043 | 0.72 | METAP2 (0.37) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |