Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046285 | 0.86 | GPR84 (0.35) | METAP2METAP1 | |
| SCHEMBL4054698 | 0.84 | ADORA3 (0.40) | METAP2METAP1EGLN1 | |
| SCHEMBL4047234 | 0.83 | GPR84 (0.43) | METAP2METAP1 | |
| SCHEMBL4043723 | 0.81 | METAP2 (0.41) | METAP2METAP1EGLN1 | |
| SCHEMBL13905132 | 0.80 | METAP2 (0.33) | METAP2METAP1 | |
| SCHEMBL4047016 | 0.80 | METAP2 (0.33) | METAP2METAP1 | |
| SCHEMBL4048086 | 0.78 | METAP2 (0.39) | METAP2METAP1EGLN1 | |
| SCHEMBL4048550 | 0.76 | ADORA3 (0.33) | METAP2METAP1 | |
| SCHEMBL21202347 | 0.75 | ELANE (0.38) | RAB9AKMT2A | |
| SCHEMBL18786110 | 0.75 | NUDT1 (0.49) | METAP2METAP1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |