Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.43 |
| ▸ | CTSL | P07711 | 6/20 | 0.43 |
| ▸ | CTSS | P25774 | 6/20 | 0.43 |
| ▸ | PREP | P48147 | 4/20 | 0.37 |
| ▸ | FAP | Q12884 | 4/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045548 | 0.92 | CTSK (0.51) | CTSKCTSLCTSSCTSBKDM4E | |
| SCHEMBL4042961 | 0.88 | CTSK (0.36) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4049845 | 0.87 | CTSK (0.40) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL6211734 | 0.87 | CTSK (0.57) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4045830 | 0.87 | CTSK (0.39) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4045843 | 0.86 | CTSK (0.43) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4045942 | 0.86 | CTSK (0.41) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4044283 | 0.85 | CTSK (0.45) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4043597 | 0.85 | CTSK (0.41) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4040451 | 0.85 | CTSK (0.41) | CTSKCTSLCTSSPREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |