Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | MC1R | Q01726 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049188 | 0.94 | CTSK (0.40) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4046943 | 0.92 | CTSK (0.50) | CTSKMC4RMC3RMC1RCTSL | |
| SCHEMBL4045843 | 0.91 | CTSK (0.43) | CTSKCTSLCTSSCCR1PREP | |
| SCHEMBL4044655 | 0.89 | CTSK (0.39) | CTSKCTSLCTSSPREPFAP | |
| SCHEMBL4044582 | 0.88 | CTSK (0.40) | CTSKMC4RMC3RMC1RCTSL | |
| SCHEMBL4043756 | 0.88 | CTSK (0.40) | CTSKMC4RMC3RMC1RCTSL | |
| SCHEMBL4040451 | 0.88 | CTSK (0.41) | CTSKMC4RMC3RMC1RCTSL | |
| SCHEMBL6210696 | 0.88 | CTSK (0.51) | CTSKMC4RMC3RMC1RCTSL | |
| SCHEMBL4047535 | 0.88 | MC4R (0.38) | CTSKMC4RMC3RMC1RCTSL | |
| SCHEMBL4049845 | 0.87 | CTSK (0.40) | CTSKMC4RMC3RMC1RCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |