Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.41 |
| ▸ | PREP | P48147 | 4/20 | 0.37 |
| ▸ | FAP | Q12884 | 4/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | MC1R | Q01726 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049243 | 0.93 | CTSK (0.44) | CTSKCTSLCTSSTGM2ELANE | |
| SCHEMBL4042251 | 0.92 | CTSK (0.50) | CTSKCTSLCTSSMEN1KMT2A | |
| SCHEMBL4045843 | 0.89 | CTSK (0.43) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4045942 | 0.89 | CTSK (0.41) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4041473 | 0.88 | CTSS (0.41) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4043597 | 0.88 | CTSK (0.41) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4044691 | 0.88 | PREP (0.35) | CTSKPREPFAPELANEMC4R | |
| SCHEMBL4049845 | 0.87 | CTSK (0.40) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4046503 | 0.86 | CTSL (0.37) | CTSKPREPFAPCTSLCTSS | |
| SCHEMBL4049188 | 0.85 | CTSK (0.40) | CTSKPREPFAPCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-A1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008017989-A1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-02-14 | — | — | WO | disclosed |