Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL159472 | 0.81 | KMT2A (0.63) | LMNAKMT2AGAAHSD17B10MAPT | |
| SCHEMBL6635884 | 0.75 | ATM (0.47) | LMNAKMT2AHSD17B10TP53MAPT | |
| SCHEMBL2388670 | 0.75 | ALDH1A1 (0.57) | KMT2AMEN1L3MBTL1POLBALDH1A1 | |
| SCHEMBL3080759 | 0.73 | SMYD2 (0.54) | LMNAKMT2AGAAMAPTMEN1 | |
| SCHEMBL158021 | 0.73 | GAA (0.41) | LMNAKMT2AGAAHSD17B10MAPT | |
| SCHEMBL160225 | 0.73 | NPSR1 (0.47) | LMNAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3081798 | 0.72 | ALDH1A1 (0.40) | KMT2ASLC6A2SLC6A3MAPTALDH1A1 | |
| SCHEMBL6963777 | 0.70 | CTSL (0.43) | GAA | |
| SCHEMBL1490709 | 0.70 | L3MBTL1 (0.55) | LMNAKMT2AGAAL3MBTL1POLB | |
| SCHEMBL3313893 | 0.70 | GAA (0.41) | LMNAKMT2AGAAHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | disclosed |